Sinsemilla (Spanish for "without seeds") is female cannabis flower that has never been pollinated by male pollen and therefore produces no seeds. Sinsemilla is the standard for high-potency commercial cannabis because unpollinated female flowers concentrate significantly more resin (and therefore more cannabinoids and terpenes) into the calyxes. When a female plant is pollinated, it redirects metabolic energy into seed production, reducing resin output. Commercial cannabis cultivators remove male plants early or use feminized seeds (seeds genetically guaranteed to produce female plants) to prevent pollination. Pre-sinsemilla-era cannabis (through the 1960s–1970s) often contained significant seeds; the transition to sinsemilla cultivation is one of the reasons modern cannabis is dramatically more potent than historical cannabis.
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